Ref: Hepatosplenomegaly

1. Hepatomegaly DDx
2. Splenomegaly DDx
3. Hepatosplenomegaly DDx

Hepatomegaly DDx

• Marked enlargement:
  • Alcoholism
  • RHF
  • Carcinoma: metastases, or 1°
• Moderate enlargement:
  • Leukemia, lymphomas, etc.
  • Fatty liver
  • Hemochromatosis
  • All marked causes
• Minor enlargement:
  • Hepatitis
  • Cirrhosis
  • Metastatic dz 
  • All marked, moderate causes

Splenomegaly DDx

• Sarcoidosis, amyloidosis
• Sjogren's
• Infectious:
  • CMV
  • IE, SBE
  • Lyme dz
  • Rheumatic fever
  • Malaria
• Lymphoid:
  • Leukemias
  • Lymphoma
• DIC

Hepatosplenomegaly DDx

• Portal HTN
• Infectious:
  • Hepatitis
  • Infectious mononucleosis
• Anemias:
  • Sickle cell
  • Pernicious
  • Thalassemia
• Marrow:
  • Polycythemia vera
• Endocrine:
  • Acromegaly
  • Thyroid dz
• SLE