1. Presentation: UC, Crohn's
2. Gross pathology: UC, Crohn's
3. Histopathology: UC, Crohn's
4. Extraintestinals: UC, Crohn's
5. Complications: UC, Crohn's

Presentation: UC

• Bloody diarrhea.

Presentation: Crohn's

• Perianal dz.
• Abdominal pain (65%).
• Mass in abdomen.

Gross pathology: UC

• Rectum always involved.
• Moves continuous, proximally from rectum.
• Thin wall.
• Few strictures.
• Diffuse ulceration.

Gross pathology: Crohn's

• Rectum may not be involved.
• Can occur anywhere along GIT.
• Not continuous: "skip lesions".
• Thick wall.
• Strictures common.
• Cobblestone appearance.

Histopathology: UC

• No granulomas.
• Low inflammation.
• Deeper ulcers [hence named ulcerative].
• Pseduopolyps.
• Abcesses in crypts.

Histopathology: Crohn's

• Granulomas.
• More inflammation.
• Shallow ulcers.
• Fibrosis.

Extraintestinals: UC

• Sclerosing cholangitis.
• Pyoderma gangrenosum.

Extraintestinals: Crohn's

• Erythema nodosum.
• Migratory polyarthritis.
• Gallstones.

Complications: UC

• Toxic megacolon.
• Cancer.
• Strictures and fistulas are very rare.

Complications: Crohn's

• Fistulas.
• Stricture.
• Malabsorption.
• Perianal dz.
• Cancer.