1. Weight
2. Insulin injections
3. Ketoacidosis
4. Cause, genetics
5. Epidemiology, onset
6. Islet histopathology

Weight

• I: Normal weight
• II: Obese

Insulin injections

• I: Always required, since body doesn't make enough
• II: Perhaps required

Ketoacidosis

• I: Common
• II: Rare

Cause

• I: Autoimmunity against beta cells
• II: Insulin resistance, insufficiency

Genetics

• I: Low concordance
• II: High concordance
• I: HLA-DR linked
• II: No HLA-DR link

Epidemiology

• I: Incidence 15%
• II: Incidence 85%

Onset

• I: Onset <20 yo
• II: Onset >30 yo

Islet histopathology

• I: Marked beta cell reduction
• II: Moderate beta cell reduction