1. Microcytics
2. Macrocytics
3. Normocytics

Microcytics

• MICS are TICS:
• Thalassemia
• Iron deficiency
• Chronic dz
• Sideroblastic anemia (can be 2° to lead)

Macrocytics

• MACdonald's has FAB FOOD and DRINK:
• Folate deficiency
• Alcohol abuse [since concurrent thiamine deficiency]
• B12 [thiamine] deficiency
• All MACrocytics are due to a NUTRITIONAL deficiency or ALCOHOL.
• MCV>100 is macrocytic.
• Patient profile rule of thumb:
  • Old/alcoholic: B12 deficiency.
  • Young/pregnant: folate defiency.
• DDx folate from B12 deficiency: B12 deficiency has the neurological signs.

Normocytics

• ABCD:
• Acute blood loss
• Bone marrow failure
• Chronic dz
• Destruction: hemolytics, which are SHEEP TIT:
  • Sickle cell
  • Hereditary spherocytosis
  • Enzyme deficiencies: G6P, pyruvate kinase
  • Erythroblastosis fetalis
  • Paroxysmal nocturnal hemoglobinuria
  • Trauma to RBCs
  • Immunohemolytics: warm Ab, cold Ag
  • Thalassemias